TGM3 and UCHL5

Data Source:
BioGRID (pull down)

		TGM3	UCHL5
Description		transglutaminase 3	ubiquitin C-terminal hydrolase L5
Image
GO Annotations	Cellular Component	Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Extracellular Exosome	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Catalytic Activity Structural Molecule Activity Calcium Ion Binding Transferase Activity, Transferring Acyl Groups	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Cysteine-type Peptidase Activity Proteasome Binding
	Biological Process	Cellular Protein Modification Process Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Hair Follicle Morphogenesis Keratinization Cell Envelope Organization	DNA Repair DNA Recombination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process
Pathways			Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Monophosphate B-2-Octylglucoside Guanosine-5'-Diphosphate
Diseases
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Inflammatory skin disease ( 25574825) Keratinocyte cancer (MTAG) ( 31174203) Metabolite levels ( 23823483) Non-melanoma skin cancer ( 29739929)	Cannabis dependence ( 21668797)
Interacting Genes		2 interacting genes: CALML5 UCHL5	102 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA NFRKB PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		7053	51377
HPRD ID		02584	10293
Ensembl ID		ENSG00000125780	ENSG00000116750
Uniprot IDs		Q08188	Q9Y5K5
PDB IDs		1L9M 1L9N 1NUD 1NUF 1NUG	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?
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