TFR2 and SEC22A

Data Source:
BioGRID (two hybrid)

		TFR2	SEC22A
Description		transferrin receptor 2	SEC22 homolog A, vesicle trafficking protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Transferrin Receptor Activity Protein Binding Co-receptor Binding	Transporter Activity Protein Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Acute-phase Response Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport
Pathways		Transferrin endocytosis and recycling	COPII-mediated vesicle transport
Drugs		Ferrous sulfate anhydrous Ferric derisomaltose
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Apolipoprotein B levels ( 32203549) Eosinophil counts ( 32888494) Hematocrit ( 32888494 27863252 28017375 19862010) Hematological parameters ( 19820697) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 28453575 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494 27863252)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		5 interacting genes: HFE OLFM4 SEC22A SOCS3 TF	106 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC14A2 SLC30A2 SLC35C2 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM159 TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27
Entrez ID		7036	26984
HPRD ID		05282	15313
Ensembl ID		ENSG00000106327	ENSG00000121542
Uniprot IDs		Q9UP52	Q96IW7
PDB IDs
Enriched GO Terms of Interacting Partners?
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