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SEC22A and PHB
Data Source:
BioGRID
(two hybrid)
SEC22A
PHB
Description
SEC22 homolog A, vesicle trafficking protein
prohibitin
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Postsynaptic Density
Membrane
Mitochondrial Crista
Extrinsic Component Of Mitochondrial Outer Membrane
Mitochondrial Prohibitin Complex
Extracellular Exosome
Extrinsic Component Of Presynaptic Active Zone Membrane
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
Transporter Activity
Protein Binding
Complement Component C3a Binding
Complement Component C3b Binding
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Biological Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Protein Transport
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Ovarian Follicle Atresia
Osteoblast Differentiation
Immunoglobulin Production
Regulation Of Transcription, DNA-templated
Mitochondrial Calcium Ion Transmembrane Transport
Mitochondrion Organization
Signal Transduction
Activation Of Phospholipase C Activity
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Death
Negative Regulation Of Transcription By Competitive Promoter Binding
Histone Deacetylation
CD40 Signaling Pathway
Negative Regulation Of Cell Growth
Animal Organ Regeneration
Interleukin-17 Production
Response To Immobilization Stress
RIG-I Signaling Pathway
B Cell Activation
Negative Regulation Of Protein Catabolic Process
Response To Drug
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Modulation By Host Of Viral RNA Genome Replication
Response To Ethanol
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Complement Activation
Viral Entry Into Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
T-helper 17 Type Immune Response
Antiviral Innate Immune Response
Positive Regulation Of NIK/NF-kappaB Signaling
Activation Of Protein Kinase C Activity
Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways
COPII-mediated vesicle transport
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Drugs
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Gestational age at birth (maternal effect) (
28877031
)
Asthma (
31959851
30929738
32296059
29273806
)
Asthma (adult onset) (
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Cancer (
29299148
)
Coronary artery disease (
29212778
33020668
)
Diastolic blood pressure (
19430483
27841878
)
Lower body strength (
27325353
)
Metabolite levels (
23823483
)
Prostate cancer (
23535732
)
Refractive error (
32231278
)
Restricted and repetitive behaviours in autism spectrum disorder (
28533516
)
Systolic blood pressure (
27841878
30578418
)
Interacting Genes
106 interacting genes:
ADGRG3
AQP6
ASGR2
ATP6AP2
BIK
BNIP3
C10orf67
C16orf54
C16orf92
CALN1
CD207
CD300A
CD7
CD74
CISD2
CLEC10A
CLEC12B
CLEC2D
CLEC7A
CREB3L1
CYB561
CYBRD1
DDIT4L
DIABLO
DTX2
EDA
ELOVL4
ERLIN1
ERVFRD-1
FAM174A
FAM209A
FATE1
FUT3
GAD2
GGT6
GJB5
GJB6
GPR37L1
GRAMD2B
HAVCR2
HCST
HSD17B11
ICAM3
KCNJ2
LDLRAD1
LHFPL5
LMNA
LPAR6
LRRC25
LSMEM2
MCOLN1
MFF
MGST2
MINAR1
MS4A14
MS4A3
MS4A4A
MSR1
OPRM1
PACC1
PEX12
PHB
PTGES
RASGRP4
RETREG3
RILPL1
RNASEK
RNF144A
RNF19B
RNF5
SAR1A
SCN3B
SDHAF2
SFTPC
SLC14A2
SLC30A2
SLC35C2
SLC39A2
SMIM3
SPAG4
STMN4
STOML3
STX1A
STX2
STX4
SUSD3
SYNE4
TFR2
TLCD4
TMED9
TMEM106C
TMEM159
TMEM174
TMEM237
TMEM45B
TMEM52B
TMEM71
TMEM79
TMIE
TMPRSS2
TNFSF14
TP53INP1
TRAT1
TRIM59
TYRP1
ZFYVE27
25 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP3K10
MCM2
NCOR1
PTEN
RAF1
RB1
RBL1
RBL2
SEC22A
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
Entrez ID
26984
5245
HPRD ID
15313
01454
Ensembl ID
ENSG00000121542
ENSG00000167085
Uniprot IDs
Q96IW7
A8K401
P35232
Q53FV0
PDB IDs
1LU7
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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