TFF1 and TSG101

Data Source:
BioGRID (two hybrid)

		TFF1	TSG101
Description		trefoil factor 1	tumor susceptibility 101
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	ESCRT I Complex Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Microtubule Organizing Center Cytosol Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane Host Cell Extracellular Exosome Flemming Body
	Molecular Function	Protein Binding Growth Factor Activity	DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Coactivator Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding
	Biological Process	Carbohydrate Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Protein Monoubiquitination Extracellular Transport Cell Cycle Arrest Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Transcription, DNA-templated Viral Budding Cell Division Intracellular Transport Of Virus Autophagosome Maturation Regulation Of Viral Release From Host Cell Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis
Pathways		Estrogen-dependent gene expression	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs		Raloxifene Afimoxifene
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Pancreatic cancer ( 22158540)
Interacting Genes		20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250	120 interacting genes: AATF ADRB2 AJUBA AKAP9 AR ARRDC1 BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GMCL1 GOLM1 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 PDCD6IP PDLIM7 PIAS1 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SNAPIN SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNIP1 TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 ZWINT
Entrez ID		7031	7251
HPRD ID		00219	03229
Ensembl ID		ENSG00000160182	ENSG00000074319
Uniprot IDs		P04155	Q99816
PDB IDs		1HI7 1PS2 6V1D	1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6VME
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?