TFF1 and MUC6

Data Source:
HPRD (in vitro)

		TFF1	MUC6
Description		trefoil factor 1	mucin 6, oligomeric mucus/gel-forming
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Golgi Lumen Plasma Membrane Extracellular Matrix
	Molecular Function	Protein Binding Growth Factor Activity	Extracellular Matrix Structural Constituent
	Biological Process	Carbohydrate Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone	Stimulatory C-type Lectin Receptor Signaling Pathway O-glycan Processing Maintenance Of Gastrointestinal Epithelium
Pathways		Estrogen-dependent gene expression	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		Raloxifene Afimoxifene
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Pancreatic cancer ( 22158540)	Asthma ( 31959851) Asthma (adult onset) ( 31036433) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250	1 interacting genes: TFF1
Entrez ID		7031	4588
HPRD ID		00219	11830
Ensembl ID		ENSG00000160182	ENSG00000184956
Uniprot IDs		P04155	Q6W4X9
PDB IDs		1HI7 1PS2 6V1D
Enriched GO Terms of Interacting Partners?
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