MUC6 and TFF1

Data Source:
HPRD (in vitro)

		MUC6	TFF1
Description		mucin 6, oligomeric mucus/gel-forming	trefoil factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Golgi Lumen Plasma Membrane Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent	Protein Binding Growth Factor Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway O-glycan Processing Maintenance Of Gastrointestinal Epithelium	Carbohydrate Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Estrogen-dependent gene expression
Drugs			Raloxifene Afimoxifene
Diseases
GWAS		Asthma ( 31959851) Asthma (adult onset) ( 31036433) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)	Blood protein levels ( 30072576 29875488) Pancreatic cancer ( 22158540)
Interacting Genes		1 interacting genes: TFF1	20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250
Entrez ID		4588	7031
HPRD ID		11830	00219
Ensembl ID		ENSG00000184956	ENSG00000160182
Uniprot IDs		Q6W4X9	P04155
PDB IDs			1HI7 1PS2 6V1D
Enriched GO Terms of Interacting Partners?
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