PPP1R11 and LATS1

Data Source:
BioGRID (enzymatic study)

		PPP1R11	LATS1
Description		protein phosphatase 1 regulatory inhibitor subunit 11	large tumor suppressor kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Spindle Pole Nucleus Microtubule Organizing Center Cytosol Midbody
	Molecular Function	Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Phosphoprotein Phosphatase Activity Defense Response To Gram-positive Bacterium	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Lipid metabolism phenotypes ( 22286219)	Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		8 interacting genes: IFT20 LATS1 PPP1CA PPP1CB PPP1CC UBXN2B VCP YAF2	48 interacting genes: ALPP APP ARPC3 AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I UBQLN2 WWOX WWP1 WWTR1 ZYX
Entrez ID		6992	9113
HPRD ID		09449	09147
Ensembl ID		ENSG00000204619	ENSG00000131023
Uniprot IDs		A2BEK1 O60927	O95835
PDB IDs			4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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