CD3D and TRB

Data Source:
HPRD (in vivo)

		CD3D	TRB
Description		CD3d molecule	T cell receptor beta locus
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Integral Component Of Membrane Alpha-beta T Cell Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Signaling Receptor Activity
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization	Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Muromonab Blinatumomab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Pulse pressure ( 27841878)	Narcolepsy ( 24204295)
Interacting Genes		12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB	14 interacting genes: CD1D CD247 CD3D CD3E CD3G CTCF HLA-A HLA-B HLA-DRB1 NCOA6 TAF1B TRA TRAT1 TRD
Entrez ID		915	6957
HPRD ID		01730	01739
Ensembl ID		ENSG00000167286
Uniprot IDs		B0YIY4 P04234
PDB IDs		1XIW 6JXR
Enriched GO Terms of Interacting Partners?
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