TAC1 and PREP

Data Source:
HPRD (in vitro)

		TAC1	PREP
Description		tachykinin precursor 1	prolyl endopeptidase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body Synapse	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Substance P Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Oligopeptidase Activity
	Biological Process	Positive Regulation Of Acute Inflammatory Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion	Proteolysis
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs			1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)	Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6	7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1
Entrez ID		6863	5550
HPRD ID		08876	02673
Ensembl ID		ENSG00000006128	ENSG00000085377
Uniprot IDs		P20366 Q9Y494	B2RAH7 P48147
PDB IDs		2B19 2KS9 2KSA 2KSB 4HOM	3DDU
Enriched GO Terms of Interacting Partners?
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