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EIF4EBP1 and MLST8
Data Source:
BioGRID
(enzymatic study)
EIF4EBP1
MLST8
Description
eukaryotic translation initiation factor 4E binding protein 1
MTOR associated protein, LST8 homolog
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Protein-containing Complex
Glutamatergic Synapse
Postsynaptic Cytosol
Nucleoplasm
Cytoplasm
Cytosol
TORC1 Complex
TORC2 Complex
Molecular Function
Protein Binding
Eukaryotic Initiation Factor 4E Binding
Translation Repressor Activity
Protein Phosphatase 2A Binding
Protein Binding
Protein Serine/threonine Kinase Activator Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Response To Ischemia
Lung Development
Negative Regulation Of Protein-containing Complex Assembly
TOR Signaling
Response To Ethanol
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Translational Initiation
Cellular Response To Hypoxia
Response To Amino Acid Starvation
Cell Cycle Arrest
Regulation Of Macroautophagy
TOR Signaling
Positive Regulation Of TOR Signaling
Activation Of Protein Kinase B Activity
Regulation Of Actin Cytoskeleton Organization
TORC1 Signaling
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cellular Response To Heat
Pathways
mTORC1-mediated signalling
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
PIP3 activates AKT signaling
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Drugs
Diseases
GWAS
Menopause (age at onset) (
29773799
)
Height (
28552196
)
Interacting Genes
38 interacting genes:
AKT1
ATM
BUB1
CHTF8
CSNK2A1
CSNK2A2
DDIT4L
EIF4E
EIF4E1B
EIF4E2
GSK3B
IRAK4
LATS1
LMO2
LRRK2
MAPK1
MAPK14
MAPKAPK5
MEOX1
MLST8
MTOR
MVD
PICK1
POU6F2
PPP2CA
PRKCA
PRKDC
PTPA
REL
RHEBL1
RICTOR
RORC
RPS6KA5
RPS6KB1
RPTOR
STK3
TCF4
ZNF655
7 interacting genes:
A2M
APPL2
ATXN1
EIF4EBP1
MTOR
PRMT1
RPTOR
Entrez ID
1978
64223
HPRD ID
03746
17031
Ensembl ID
ENSG00000187840
ENSG00000167965
Uniprot IDs
Q13541
Q9BVC4
PDB IDs
1EJ4
1EJH
1WKW
2JGB
2JGC
2V8W
2V8X
2V8Y
3HXG
3HXI
3M93
3M94
3U7X
4UED
5BXV
5EKV
5NVN
5WBJ
6BCU
6BCX
4JSN
4JSP
4JSV
4JSX
4JT5
4JT6
5FLC
5H64
5WBU
5WBY
5ZCS
6BCU
6BCX
6SB0
6SB2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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