EIF4EBP1 and CHTF8

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF4EBP1	CHTF8
Description		eukaryotic translation initiation factor 4E binding protein 1	chromosome transmission fidelity factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol	Nucleus Ctf18 RFC-like Complex
	Molecular Function	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding	DNA Clamp Loader Activity Single-stranded DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation	DNA Replication Mitotic Sister Chromatid Cohesion DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Menopause (age at onset) ( 29773799)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655	6 interacting genes: AP4M1 DSCC1 EIF4EBP1 PCNA RFC3 WBP4
Entrez ID		1978	54921
HPRD ID		03746	16797
Ensembl ID		ENSG00000187840	ENSG00000168802
Uniprot IDs		Q13541	P0CG13
PDB IDs		1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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