SSR4 and HECW1

Data Source:
HPRD (in vitro, two hybrid)

		SSR4	HECW1
Description		signal sequence receptor subunit 4	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endomembrane System Integral Component Of Membrane Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function		Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		SRP-dependent cotranslational protein targeting to membrane	Degradation of DVL
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Bone mineral density (Ward's triangle area) ( 27397699) Caudal anterior-cingulate cortex volume ( 31530798) Cerebrospinal fluid AB1-42 levels ( 26252872) Delirium ( 29631748) Diverticular disease ( 28585551) Irritable bowel syndrome ( 29673008) Lung cancer in ever smokers ( 28604730) Mercury levels ( 26025379) Obesity-related traits ( 23251661) Serum galactose-deficient IgA1 levels ( 28187132) Type 2 diabetes ( 25102180)
Interacting Genes		5 interacting genes: HECW1 NLGN3 POMP PTEN SSR3	16 interacting genes: CACNA1A DVL1 GFI1B SCNN1A SCNN1B SSR4 TNK2 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2J2 UBE2L3 USP7 VAX1
Entrez ID		6748	23072
HPRD ID		02101	11385
Ensembl ID		ENSG00000180879	ENSG00000002746
Uniprot IDs		P51571	Q76N89
PDB IDs			3L4H
Enriched GO Terms of Interacting Partners?
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