SRP19 and KPNA1

Data Source:
HPRD (in vitro)

		SRP19	KPNA1
Description		signal recognition particle 19	karyopherin subunit alpha 1
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GO Annotations	Cellular Component	Nucleolus Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Signal Recognition Particle	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Ribosome Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Modulation By Virus Of Host Cellular Process Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
Drugs
Diseases
GWAS			Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		8 interacting genes: APP IPO5 IPO7 IPO8 KPNA1 MAPK8IP2 SRP54 TNPO1	45 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMNB1 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1
Entrez ID		6728	3836
HPRD ID		01644	02819
Ensembl ID		ENSG00000153037	ENSG00000114030
Uniprot IDs		A0A087WYR0 A0A2U3TZN1 P09132	B3KXZ2 P52294
PDB IDs		1JID 1MFQ 1RY1 2J37 3KTV 4P3E 5M73	2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?
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