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SREBF1 and NR0B1
Data Source:
BioGRID
(two hybrid)
HPRD
(in vitro)
SREBF1
NR0B1
Description
sterol regulatory element binding transcription factor 1
nuclear receptor subfamily 0 group B member 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
Protein-containing Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Nuclear Speck
Centriolar Satellite
Polysomal Ribosome
Intracellular Membrane-bounded Organelle
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Protein Kinase Binding
Sterol Response Element Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Transcription Corepressor Activity
RNA Binding
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
DNA Hairpin Binding
Steroid Hormone Receptor Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Heart Rate By Chemical Signal
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Aging
Circadian Rhythm
Cholesterol Metabolic Process
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Glucose
Positive Regulation Of Triglyceride Biosynthetic Process
Lipid Localization
Regulation Of Lipid Storage
Regulation Of Fatty Acid Metabolic Process
Lung Development
Intracellular Receptor Signaling Pathway
Positive Regulation Of Histone Deacetylation
Regulation Of Protein Stability
Response To Food
Response To Retinoic Acid
Response To Progesterone
SREBP Signaling Pathway
Response To Glucagon
Response To Drug
MRNA Transcription By RNA Polymerase II
Fat Cell Differentiation
Response To Ethanol
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Secretion
Response To CAMP
Cellular Response To Fatty Acid
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Spermatogenesis
Protein Localization
Gonad Development
Male Gonad Development
Negative Regulation Of Steroid Biosynthetic Process
Hypothalamus Development
Pituitary Gland Development
Male Sex Determination
Adrenal Gland Development
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Leydig Cell Differentiation
Response To Immobilization Stress
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Transcription, DNA-templated
Sertoli Cell Differentiation
Pathways
RORA activates gene expression
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Doconexent
Omega-3-acid ethyl esters
Omega-3 fatty acids
Fish oil
Dexamethasone
Dexamethasone acetate
Diseases
Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Coffee consumption (
31046077
)
Eosinophil counts (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Parkinson's disease (
21738487
)
Resting heart rate (
27798624
)
Schizophrenia (
28991256
25056061
29483656
)
TB-LM or TBLH-BMD (pleiotropy) (
28743860
)
White blood cell count (
32888494
)
Interacting Genes
40 interacting genes:
AR
ATXN1
ATXN1L
CDK8
CREBBP
EP300
ESR1
ESR2
FBXW7
GSK3B
HNF4A
ID2
ID3
KLF13
LMNA
MAPK1
MAPK3
MED1
MED12
MED13
MED14
MED17
MED23
MED24
MED25
MED26
MED6
MED7
MTNR1B
NR0B1
NR5A2
PLK1
PRMT5
SMARCD3
SP1
SUMO1
TWIST2
UBE2I
YY1
ZBTB7C
17 interacting genes:
AR
COPS2
EEF2KMT
ESR1
ESR2
ESRRA
ESRRG
NR3C1
NR5A1
NRIP1
PGR
POU5F1
PPARG
RNF31
RORA
SNW1
SREBF1
Entrez ID
6720
190
HPRD ID
01701
08362
Ensembl ID
ENSG00000072310
ENSG00000169297
Uniprot IDs
A8MTU8
B3KR77
P36956
F1D8P4
P51843
PDB IDs
1AM9
4RWV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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