SREBF1 and TWIST2

Data Source:
HPRD (two hybrid, in vitro)

		SREBF1	TWIST2
Description		sterol regulatory element binding transcription factor 1	twist family bHLH transcription factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Protein Kinase Binding Sterol Response Element Binding Protein-containing Complex Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Rate By Chemical Signal Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Lipid Localization Regulation Of Lipid Storage Regulation Of Fatty Acid Metabolic Process Lung Development Intracellular Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Regulation Of Protein Stability Response To Food Response To Retinoic Acid Response To Progesterone SREBP Signaling Pathway Response To Glucagon Response To Drug MRNA Transcription By RNA Polymerase II Fat Cell Differentiation Response To Ethanol Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Cell Differentiation Positive Regulation Of Cell Migration Developmental Process Negative Regulation Of Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated
Pathways		RORA activates gene expression FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Transcriptional regulation by RUNX2
Drugs		Doconexent Omega-3-acid ethyl esters Omega-3 fatty acids Fish oil
Diseases
GWAS		Coffee consumption ( 31046077) Eosinophil counts ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Parkinson's disease ( 21738487) Resting heart rate ( 27798624) Schizophrenia ( 28991256 25056061 29483656) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) White blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Chronic obstructive pulmonary disease ( 30804561) Male-pattern baldness ( 29146897 27182965 28196072) Morning person ( 30696823) Rosacea symptom severity ( 29771307) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		40 interacting genes: AR ATXN1 ATXN1L CDK8 CREBBP EP300 ESR1 ESR2 FBXW7 GSK3B HNF4A ID2 ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 MTNR1B NR0B1 NR5A2 PLK1 PRMT5 SMARCD3 SP1 SUMO1 TWIST2 UBE2I YY1 ZBTB7C	9 interacting genes: CRK FERD3L GLIS2 MEF2C PLCG2 SREBF1 TCF12 TCF3 TCF4
Entrez ID		6720	117581
HPRD ID		01701	09616
Ensembl ID		ENSG00000072310	ENSG00000233608
Uniprot IDs		A8MTU8 B3KR77 P36956	A1MB48 Q8WVJ9
PDB IDs		1AM9
Enriched GO Terms of Interacting Partners?
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