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SREBF1 and MED26
Data Source:
BioGRID
(biochemical, affinity chromatography technology, pull down)
SREBF1
MED26
Description
sterol regulatory element binding transcription factor 1
mediator complex subunit 26
Image
GO Annotations
Cellular Component
Golgi Membrane
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
Protein-containing Complex
Nucleoplasm
Mediator Complex
Core Mediator Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Protein Kinase Binding
Sterol Response Element Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Heart Rate By Chemical Signal
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Aging
Circadian Rhythm
Cholesterol Metabolic Process
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Glucose
Positive Regulation Of Triglyceride Biosynthetic Process
Lipid Localization
Regulation Of Lipid Storage
Regulation Of Fatty Acid Metabolic Process
Lung Development
Intracellular Receptor Signaling Pathway
Positive Regulation Of Histone Deacetylation
Regulation Of Protein Stability
Response To Food
Response To Retinoic Acid
Response To Progesterone
SREBP Signaling Pathway
Response To Glucagon
Response To Drug
MRNA Transcription By RNA Polymerase II
Fat Cell Differentiation
Response To Ethanol
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Secretion
Response To CAMP
Cellular Response To Fatty Acid
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein Targeting To Mitochondrion
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Pathways
RORA activates gene expression
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Drugs
Doconexent
Omega-3-acid ethyl esters
Omega-3 fatty acids
Fish oil
Diseases
GWAS
Coffee consumption (
31046077
)
Eosinophil counts (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Parkinson's disease (
21738487
)
Resting heart rate (
27798624
)
Schizophrenia (
28991256
25056061
29483656
)
TB-LM or TBLH-BMD (pleiotropy) (
28743860
)
White blood cell count (
32888494
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Interacting Genes
40 interacting genes:
AR
ATXN1
ATXN1L
CDK8
CREBBP
EP300
ESR1
ESR2
FBXW7
GSK3B
HNF4A
ID2
ID3
KLF13
LMNA
MAPK1
MAPK3
MED1
MED12
MED13
MED14
MED17
MED23
MED24
MED25
MED26
MED6
MED7
MTNR1B
NR0B1
NR5A2
PLK1
PRMT5
SMARCD3
SP1
SUMO1
TWIST2
UBE2I
YY1
ZBTB7C
8 interacting genes:
AURKA
CDK8
CTDP1
MED12
MED8
MED9
RBP1
SREBF1
Entrez ID
6720
9441
HPRD ID
01701
05437
Ensembl ID
ENSG00000072310
ENSG00000105085
Uniprot IDs
A8MTU8
B3KR77
P36956
O95402
PDB IDs
1AM9
5ODD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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