SPTBN2 and CELSR3

Data Source:
HPRD (two hybrid)

		SPTBN2	CELSR3
Description		spectrin beta, non-erythrocytic 2	cadherin EGF LAG seven-pass G-type receptor 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Spectrin Apical Plasma Membrane Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Structural Constituent Of Synapse	G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping Postsynapse Organization	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cell-cell Adhesion
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 28115744 21926972 31043756)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B	12 interacting genes: CLK1 CLUH DST IFT140 SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA
Entrez ID		6712	1951
HPRD ID		05404	09179
Ensembl ID		ENSG00000173898	ENSG00000008300
Uniprot IDs		O15020	Q9NYQ7
PDB IDs		1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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