SPTBN2 and ACTR1A

Data Source:
HPRD (in vivo)

		SPTBN2	ACTR1A
Description		spectrin beta, non-erythrocytic 2	actin related protein 1A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Spectrin Apical Plasma Membrane Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton	Manchette Cytoplasm Centrosome Centriole Cytosol Dynactin Complex Microtubule Associated Complex Microtubule Cytoskeleton COPI-coated Vesicle Extracellular Exosome Cell Cortex Region
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Structural Constituent Of Synapse	Protein Binding ATP Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Synapse Assembly Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellar Purkinje Cell Layer Morphogenesis Adult Behavior Multicellular Organism Growth Actin Filament Capping Postsynapse Organization	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking
Pathways		MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 28115744 21926972 31043756)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B	5 interacting genes: DCTN1 DCTN4 NUMA1 SPTBN1 SPTBN2
Entrez ID		6712	10121
HPRD ID		05404	05507
Ensembl ID		ENSG00000173898	ENSG00000138107
Uniprot IDs		O15020	A0A384NQ21 P61163
PDB IDs		1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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