CELSR3 and SPTBN4

Data Source:
HPRD (two hybrid)

		CELSR3	SPTBN4
Description		cadherin EGF LAG seven-pass G-type receptor 3	spectrin beta, non-erythrocytic 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber
	Molecular Function	G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cell-cell Adhesion	MAPK Cascade Regulation Of Sodium Ion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane
Pathways			NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mental health study participation (provided email address) ( 31263887) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)
Interacting Genes		12 interacting genes: CLK1 CLUH DST IFT140 SCAPER SGSM2 SPTBN2 SPTBN4 SWAP70 TRIP12 TSPYL4 UACA	15 interacting genes: ANK3 ARC CDC37 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		1951	57731
HPRD ID		09179	09372
Ensembl ID		ENSG00000008300	ENSG00000160460
Uniprot IDs		Q9NYQ7	Q9H254
PDB IDs
Enriched GO Terms of Interacting Partners?
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