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SPTBN2

Description spectrin beta, non-erythrocytic 2
Image
GO Annotations Cellular Component
  • Extracellular Space
  • Cytosol
  • Spectrin
  • Apical Plasma Membrane
  • Neuronal Cell Body
  • Parallel Fiber To Purkinje Cell Synapse
  • Presynapse
  • Glutamatergic Synapse
  • Postsynaptic Spectrin-associated Cytoskeleton
Molecular Function
  • Actin Binding
  • Structural Constituent Of Cytoskeleton
  • Phospholipid Binding
  • Cadherin Binding
  • Structural Constituent Of Synapse
Biological Process
  • MAPK Cascade
  • Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
  • Cytoskeleton Organization
  • Axon Guidance
  • Synapse Assembly
  • Vesicle-mediated Transport
  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
  • Cerebellar Purkinje Cell Layer Morphogenesis
  • Adult Behavior
  • Multicellular Organism Growth
  • Actin Filament Capping
  • Postsynapse Organization
Pathways
  • MHC class II antigen presentation
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • Interaction between L1 and Ankyrins
  • Interaction between L1 and Ankyrins
  • RAF/MAP kinase cascade
  • COPI-mediated anterograde transport
Drugs
Diseases
  • Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
  • Bipolar disorder ( 28115744 21926972 31043756)
Interacting Genes 11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B
Entrez ID 6712
HPRD ID 05404
Ensembl ID ENSG00000173898
Uniprot IDs O15020
PDB IDs 1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2023