SPP1 and PLCB2

Data Source:
BioGRID (affinity chromatography technology)

		SPP1	PLCB2
Description		secreted phosphoprotein 1	phospholipase C beta 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding
	Biological Process	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	7 interacting genes: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7
Entrez ID		6696	5330
HPRD ID		01325	04985
Ensembl ID		ENSG00000118785	ENSG00000137841
Uniprot IDs		A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0	Q00722 Q59F77 Q9BVT6
PDB IDs		3CXD 3DSF	2FJU 2ZKM
Enriched GO Terms of Interacting Partners?
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