SPP1 and CHD1

Data Source:
BioGRID (two hybrid)

		SPP1	CHD1
Description		secreted phosphoprotein 1	chromodomain helicase DNA binding protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Methylated Histone Binding
	Biological Process	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion	Regulation Of Transcription By RNA Polymerase II Covalent Chromatin Modification DNA Duplex Unwinding Positive Regulation By Host Of Viral Transcription
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation	Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)	Basophil percentage of white cells ( 27863252) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Periodontitis (Mean PAL) ( 24024966) Renal sinus fat ( 22044751)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	9 interacting genes: BCLAF1 H3-3A H3-4 HDAC1 NCOR1 SAFB SPP1 SRSF3 SSRP1
Entrez ID		6696	1105
HPRD ID		01325	03668
Ensembl ID		ENSG00000118785	ENSG00000153922
Uniprot IDs		A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0	B3KT33 O14646
PDB IDs		3CXD 3DSF	2B2T 2B2U 2B2V 2B2W 2B2Y 2N39 4B4C 4NW2 4O42 5AFW
Enriched GO Terms of Interacting Partners?
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