PLCB2 and TRPC3

Data Source:
HPRD (in vivo)

		PLCB2	TRPC3
Description		phospholipase C beta 2	transient receptor potential cation channel subfamily C member 3
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GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Phospholipid Metabolic Process G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Wnt Signaling Pathway, Calcium Modulating Pathway Lipid Catabolic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Sensory Perception Of Bitter Taste	Calcium Ion Transport Manganese Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels
Drugs
Diseases
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Neutrophil count ( 32888494) Schizophrenia ( 25056061 29483656) White blood cell count ( 32888494)	Asthma ( 31959851) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)
Interacting Genes		7 interacting genes: GNAQ MAP2K3 MAP2K6 SLC9A3R1 SNCA TRPC3 TRPM7	20 interacting genes: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		5330	7222
HPRD ID		04985	15999
Ensembl ID		ENSG00000137841	ENSG00000138741
Uniprot IDs		Q00722 Q59F77 Q9BVT6	Q13507
PDB IDs		2FJU 2ZKM	5ZBG 6CUD 6D7L 6DJS
Enriched GO Terms of Interacting Partners?
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