SPP1 and MAP1B

Data Source:
BioGRID (two hybrid)

		SPP1	MAP1B
Description		secreted phosphoprotein 1	microtubule associated protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome	Photoreceptor Outer Segment Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Axon Dendrite Growth Cone Somatodendritic Compartment Neuronal Cell Body Varicosity Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Basal Dendrite Hippocampal Mossy Fiber
	Molecular Function	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding	Actin Binding Structural Molecule Activity Protein Binding Phospholipid Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Negative Regulation Of Microtubule Depolymerization Axonogenesis Synapse Assembly Response To Mechanical Stimulus Response To Carbohydrate Cellular Process Response To Inorganic Substance Peripheral Nervous System Axon Regeneration Dendrite Development Response To Insecticide Developmental Maturation Regulation Of Microtubule Depolymerization Positive Regulation Of Microtubule Polymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Vitamin A Response To Drug Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Induction Of Synaptic Plasticity By Chemical Substance Establishment Of Monopolar Cell Polarity Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus
Pathways		Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)	Attention deficit hyperactivity disorder ( 18839057) Coronary artery disease in type 1 diabetes ( 29695241) Refractive error ( 32231278)
Interacting Genes		97 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CCR8 CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DRD2 DSEL EEF1A1 EIF3K EPAS1 ERBB2 F2 FTH1 GET3 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCS1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 PTGER4 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SGTB SLC22A1 SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A	29 interacting genes: ACTB ANP32A ARHGEF11 DYNLL1 EEF1D ERBB3 FOS GABRR1 GABRR2 GAN GSK3B HTR6 LRRK2 MAG MAGOH MAP1A MAPK8 MARCHF5 MINK1 NXF1 NXF2 PAFAH1B1 RASSF1 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2
Entrez ID		6696	4131
HPRD ID		01325	01139
Ensembl ID		ENSG00000118785	ENSG00000131711
Uniprot IDs		A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0	A2BDK6 P46821 Q6PJD3 Q86X89
PDB IDs		3CXD 3DSF
Enriched GO Terms of Interacting Partners?
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