SPINT1 and ST14

Data Source:
HPRD (in vivo, in vitro)

		SPINT1	ST14
Description		serine peptidase inhibitor, Kunitz type 1	ST14 transmembrane serine protease matriptase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Neural Tube Closure Proteolysis Keratinocyte Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Cornification
Pathways		MET Receptor Activation Signaling by MST1	Formation of the cornified envelope Formation of the cornified envelope
Drugs			Urokinase Benzamidine Camostat
Diseases			Ichthyosis with hypotrichosis
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	17 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF NOTCH2 PDGFC PHB PLAU RAD51 RGS16 SPINT1 STK11 TGFB1
Entrez ID		6692	6768
HPRD ID		05494	06005
Ensembl ID		ENSG00000166145	ENSG00000149418
Uniprot IDs		O43278	Q9Y5Y6
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V	1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T
Enriched GO Terms of Interacting Partners?
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