SNCB and GRK5

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SNCB	GRK5
Description		synuclein beta	G protein-coupled receptor kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Inclusion Body Neuronal Cell Body Axon Terminus	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Transition Metal Ion Binding Cuprous Ion Binding	Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Chemical Synaptic Transmission Response To Metal Ion Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Neuron Death	Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		MTF1 activates gene expression	G alpha (q) signalling events G alpha (s) signalling events
Drugs
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
GWAS			Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 30060048) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		13 interacting genes: AKT1 APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 MORN4 PLK1 PLK3 SEPTIN4 SNCA	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6620	2869
HPRD ID		03980	02926
Ensembl ID		ENSG00000074317	ENSG00000198873
Uniprot IDs		G4Y815 G4Y816 Q16143	P34947
PDB IDs			4TNB 4TND
Enriched GO Terms of Interacting Partners?
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