GRK5 and RCVRN

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRK5	RCVRN
Description		G protein-coupled receptor kinase 5	recoverin
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Dendrite Perikaryon
	Molecular Function	Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity	Calcium Ion Binding Calcium Sensitive Guanylate Cyclase Activator Activity
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Cell Cycle	Signal Transduction Visual Perception Phototransduction Positive Regulation Of Guanylate Cyclase Activity Regulation Of Calcium Ion Transport
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Myristic acid
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 30060048) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	11 interacting genes: CAV1 GIT2 GRK1 GRK2 GRK5 GRK6 IL15RA PQBP1 SMAD3 TGFBR2 TOP1
Entrez ID		2869	5957
HPRD ID		02926	01558
Ensembl ID		ENSG00000198873	ENSG00000109047
Uniprot IDs		P34947	P35243
PDB IDs		4TNB 4TND	2D8N
Enriched GO Terms of Interacting Partners?
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