SMS and RPS6KA3

Data Source:
BioGRID (two hybrid)

		SMS	RPS6KA3
Description		spermine synthase	ribosomal protein S6 kinase A3
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Spermine Synthase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Methionine Metabolic Process Polyamine Metabolic Process Spermine Biosynthetic Process	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Metabolism of polyamines	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Spermine	Acetylsalicylic acid Fostamatinib
Diseases		Snyder-Robinson syndrome	Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS			Refractive error ( 32231278)
Interacting Genes		5 interacting genes: EZH2 MAPK6 MAPK8IP2 MAPKAPK3 RPS6KA3	40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1
Entrez ID		6611	6197
HPRD ID		02115	02092
Ensembl ID		ENSG00000102172	ENSG00000177189
Uniprot IDs		P52788	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs		3C6K 3C6M	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L
Enriched GO Terms of Interacting Partners?
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