HPD and HIVEP1

Data Source:
BioGRID (two hybrid)

		HPD	HIVEP1
Description		4-hydroxyphenylpyruvate dioxygenase	HIVEP zinc finger 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Extracellular Exosome	Nucleus Nucleoplasm Mitochondrion Cytosol Nuclear Body
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II BMP Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Tyrosine catabolism
Drugs		Nitisinone DAS869
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414)	Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 22488850) Asthma ( 32296059) Body mass index ( 28892062 25673413 29273807) Chronotype ( 30696823) Feeling worry ( 29500382) Figural/spatial cognitive ability ( 31620175) General risk tolerance (MTAG) ( 30643258) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Takayasu arteritis ( 25604533)
Interacting Genes		5 interacting genes: CDKN1A HIVEP1 IKBKG RIDA STK33	70 interacting genes: ALDOB APH1A APTX ASGR1 ATXN1 ATXN1L BANP BHLHE40 BNIP3 BRCA1 CACNA1A CCNK CDC37 CLK1 CREB1 DNAJA1 ELOA EMG1 FAM104B GAA GSDMB HPD HSPA1A IGFN1 IMMT KDF1 MAGED1 MAPK14 MAPK8 MIEN1 MTMR3 NFYC NHLH1 NINJ1 NRF1 NUCB1 OGT OTX1 PLEKHB2 POGZ POU2F1 POU6F2 PRKAR1A PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAB1A RBM47 RBPMS RIDA RNF186 ROR2 SDCBP SERTAD1 SH3KBP1 SMAD3 SNX4 SOCS3 SOX10 SP4 SRPK2 STAT3 TENT5B TMEM176A VEZF1 ZC3H10 ZFHX3
Entrez ID		3242	3096
HPRD ID		02041	01925
Ensembl ID		ENSG00000158104	ENSG00000095951
Uniprot IDs		P32754	P15822
PDB IDs		3ISQ 5EC3	1BBO 3ZNF 4ZNF
Enriched GO Terms of Interacting Partners?
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