HPD and STK33

Data Source:
BioGRID (enzymatic study)

		HPD	STK33
Description		4-hydroxyphenylpyruvate dioxygenase	serine/threonine kinase 33
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Extracellular Exosome	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	4-hydroxyphenylpyruvate Dioxygenase Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process	Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Protein Autophosphorylation
Pathways		Tyrosine catabolism
Drugs		Nitisinone DAS869	Fostamatinib
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414)	Adult body size ( 32376654) Body mass index ( 26426971 19079261 28892062 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Small cell lung carcinoma ( 28604730)
Interacting Genes		5 interacting genes: CDKN1A HIVEP1 IKBKG RIDA STK33	5 interacting genes: APP GLYCTK HPD USP15 USP5
Entrez ID		3242	65975
HPRD ID		02041	09642
Ensembl ID		ENSG00000158104	ENSG00000130413
Uniprot IDs		P32754	B3KS39 B4DDH2 F8WAK5 Q9BYT3
PDB IDs		3ISQ 5EC3
Enriched GO Terms of Interacting Partners?
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