SLC9A2 and SPTA1

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SLC9A2	SPTA1
Description		solute carrier family 9 member A2	spectrin alpha, erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Axon Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Cuticular Plate
	Molecular Function	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Actin Filament Binding
	Biological Process	Ion Transport Protein Localization Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	MAPK Cascade Lymphocyte Homeostasis Porphyrin-containing Compound Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Actin Filament Organization Axon Guidance Regulation Of Cell Shape Hemopoiesis Positive Regulation Of Protein Binding Positive Regulation Of T Cell Proliferation Actin Filament Capping
Pathways		Sodium/Proton exchangers	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases			Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Delirium ( 29631748) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917) Plateletcrit ( 32888494)	Glycated hemoglobin levels ( 20858683 28898252) Hemoglobin A1c levels ( 29844224) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Night sleep phenotypes ( 27126917) Other erythrocyte phenotypes ( 19862010) Platelet distribution width ( 32888494) QRS duration ( 27577874) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: ABL1 CHP1 CHP2 PIK3R1 RASA1 SPTA1 SPTAN1 SRC	27 interacting genes: ABI1 ABL1 ACTA1 ADD1 ANK1 BCKDK C21orf58 CCDC185 DGCR6L ENAH EVL EXOSC5 FANCC FASLG GADD45GIP1 KRT75 ODF3B PKP2 PLEC SLC9A2 SPTB SPTBN2 TSHZ2 TXN2 VASP YWHAQ ZNF326
Entrez ID		6549	6708
HPRD ID		02756	01685
Ensembl ID		ENSG00000115616	ENSG00000163554
Uniprot IDs		Q9UBY0	P02549
PDB IDs			1OWA 3LBX 5J4O
Enriched GO Terms of Interacting Partners?
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