UBE2Z and PLEKHA6

Data Source:
BioGRID (two hybrid)

		UBE2Z	PLEKHA6
Description		ubiquitin conjugating enzyme E2 Z	pleckstrin homology domain containing A6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Palmitoleic acid (16:1n-7) levels ( 23362303) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Regular attendance at a religious group ( 29970889) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD	3 interacting genes: APOE PLEKHA5 UBE2Z
Entrez ID		65264	22874
HPRD ID		08589	09685
Ensembl ID		ENSG00000159202	ENSG00000143850
Uniprot IDs		Q9H832	Q9Y2H5
PDB IDs		5A4P	2D9Y 2YRY
Enriched GO Terms of Interacting Partners?
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