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UBE2Z and RNF41
Data Source:
BioGRID
(two hybrid)
UBE2Z
RNF41
Description
ubiquitin conjugating enzyme E2 Z
ring finger protein 41
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Cytosol
Perinuclear Region Of Cytoplasm
Endoplasmic Reticulum Tubular Network
Molecular Function
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Erythropoietin Receptor Binding
Interleukin-3 Receptor Binding
Protein Binding
Zinc Ion Binding
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Small GTPase Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Negative Regulation Of Endopeptidase Activity
Protein Ubiquitination
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Protein Polyubiquitination
Autophagy
Negative Regulation Of Cell Population Proliferation
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Negative Regulation Of Cell Migration
Regulation Of MAPK Cascade
Regulation Of Lymphocyte Differentiation
Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of DNA-binding Transcription Factor Activity
Protein Autoubiquitination
Regulation Of Protein Kinase B Signaling
Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Mitophagy
Regulation Of Establishment Of Cell Polarity
Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Downregulation of ERBB2:ERBB3 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary heart disease (
21378990
)
Height (
31562340
)
Myocardial infarction (
26343387
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Type 2 diabetes (
30054458
29358691
)
Asthma (
31619474
)
Interacting Genes
39 interacting genes:
AK8
BMPR1B
CCT3
DZIP3
GORASP2
HLTF
HMBOX1
INCA1
LNX2
LPL
MDM2
OTUB1
PLEKHA6
PLEKHF2
PPP1CA
PRKN
RAPSN
REL
RNF103
RNF130
RNF139
RNF144B
RNF150
RNF166
RNF41
RNF5
SMAD1
SMAD4
SRA1
SYVN1
TGFBR1
TRAIP
TRIM27
TRIM3
TRIM46
TRIM65
UBA1
UBA6
UBD
42 interacting genes:
ADRB2
AP2S1
APP
ARL6IP4
ASB6
BIRC6
C1orf109
ENOPH1
ERBB3
ERBB4
IRS4
ISCA2
KDM3B
LEPR
LZTS2
MAGEL2
MARK2
MEOX2
MNAT1
MTNR1A
MTNR1B
MTURN
N4BP3
RAD23A
RFC4
RNF166
RRM2B
SRR
TCEANC
TRIM32
TRIM8
TSG101
TTC1
UBASH3A
UBASH3B
UBE2D3
UBE2K
UBE2U
UBE2Z
USP8
VPS52
ZAP70
Entrez ID
65264
10193
HPRD ID
08589
11520
Ensembl ID
ENSG00000159202
ENSG00000181852
Uniprot IDs
Q9H832
A0A024RB33
Q9H4P4
PDB IDs
5A4P
2FZP
2GWF
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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