SLC5A2 and AQP2

Data Source:
BioGRID (two hybrid)

		SLC5A2	AQP2
Description		solute carrier family 5 member 2	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Low-affinity Glucose:sodium Symporter Activity Glucose:sodium Symporter Activity Alpha-glucoside Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Alpha-glucoside Transport Carbohydrate Metabolic Process Sodium Ion Transport Hexose Transmembrane Transport Glucose Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane	Renal Water Homeostasis Renal Water Transport Water Transport Glycerol Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways		Cellular hexose transport Defective SLC5A2 causes renal glucosuria (GLYS1)	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Dapagliflozin Canagliflozin Empagliflozin Ertugliflozin
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS		Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		1 interacting genes: AQP2	60 interacting genes: ACTB BCAP31 C4orf3 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		6524	359
HPRD ID		08919	00141
Ensembl ID		ENSG00000140675	ENSG00000167580
Uniprot IDs		P31639	P41181
PDB IDs			4NEF 4OJ2 6QF5
Enriched GO Terms of Interacting Partners?
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