MRPL11 and THAP1

Data Source:
BioGRID (two hybrid)

		MRPL11	THAP1
Description		mitochondrial ribosomal protein L11	THAP domain containing 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Large Ribosomal Subunit	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Cycle Regulation Of Mitotic Cell Cycle
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Bipolar disorder ( 21926972) Low density lipoprotein cholesterol levels ( 32154731)	Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		32 interacting genes: AGTRAP APP CAMK2A CAMK2B CAMK2D CAMK2G CCDC172 CRYAB ERCC6 FSD2 GOLGA6L9 HMBOX1 HOMEZ JAKMIP1 JAKMIP2 KRT40 MRPL54 MTUS2 PDCL PNMA1 SLC16A9 STX2 TAX1BP1 TFCP2 TFIP11 THAP1 VPS52 ZBTB14 ZBTB2 ZBTB8A ZNF438 ZNF526	105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 C4orf45 C7orf50 CDC37 CDKN2D CHD2 CSNK2A1 DCAF8 DVL2 EEF1AKNMT FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GAS8 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526
Entrez ID		65003	55145
HPRD ID		14739	15496
Ensembl ID		ENSG00000174547	ENSG00000131931
Uniprot IDs		Q9Y3B7	Q9NVV9
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG	2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?
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