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THAP1 and FGF10
Data Source:
BioGRID
(two hybrid)
THAP1
FGF10
Description
THAP domain containing 1
fibroblast growth factor 10
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
PML Body
Intracellular Membrane-bounded Organelle
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Plasma Membrane
Cell Surface
Collagen-containing Extracellular Matrix
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Fibroblast Growth Factor Receptor Binding
Type 2 Fibroblast Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Chemoattractant Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Endothelial Cell Proliferation
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cell Cycle
Regulation Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Metanephros Development
Organ Induction
Mesonephros Development
Positive Regulation Of Protein Phosphorylation
Blood Vessel Remodeling
Metanephros Morphogenesis
Determination Of Left/right Symmetry
Salivary Gland Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Smoothened Signaling Pathway
Embryonic Pattern Specification
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Keratinocyte Proliferation
Pituitary Gland Development
Cell Differentiation
Regulation Of Cell Migration
Embryonic Genitalia Morphogenesis
Thyroid Gland Development
Otic Vesicle Formation
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pancreas Development
Hair Follicle Morphogenesis
Embryonic Camera-type Eye Development
Actin Cytoskeleton Reorganization
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of ATPase Activity
Lacrimal Gland Development
Regulation Of Activin Receptor Signaling Pathway
Protein Localization To Cell Surface
Somatic Stem Cell Population Maintenance
Wound Healing
Tissue Regeneration
Odontogenesis Of Dentin-containing Tooth
Muscle Cell Fate Commitment
Positive Regulation Of MAPK Cascade
Negative Regulation Of Cell Differentiation
Positive Regulation Of DNA Repair
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Ras Protein Signal Transduction
Regulation Of Saliva Secretion
Positive Regulation Of Fibroblast Proliferation
Spleen Development
Thymus Development
Embryonic Digestive Tract Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Female Genitalia Morphogenesis
Male Genitalia Morphogenesis
Positive Regulation Of Lymphocyte Proliferation
Epithelial Cell Proliferation
Urothelial Cell Proliferation
Positive Regulation Of Urothelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
White Fat Cell Differentiation
Positive Chemotaxis
Induction Of Positive Chemotaxis
Smooth Muscle Cell Differentiation
Positive Regulation Of Keratinocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Radial Glial Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Limb Development
Limb Bud Formation
Lung Epithelium Development
Lung Saccule Development
Bronchiole Morphogenesis
Bud Outgrowth Involved In Lung Branching
Bud Elongation Involved In Lung Branching
Mesenchymal-epithelial Cell Signaling Involved In Lung Development
Type II Pneumocyte Differentiation
Prostatic Bud Formation
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification
Mammary Gland Bud Formation
Submandibular Salivary Gland Formation
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Branch Elongation Involved In Salivary Gland Morphogenesis
Semicircular Canal Fusion
Mesenchymal Cell Differentiation Involved In Lung Development
Secretion By Lung Epithelial Cell Involved In Lung Growth
Lung Proximal/distal Axis Specification
Tear Secretion
Positive Regulation Of White Fat Cell Proliferation
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Harderian Gland Development
Negative Regulation Of Cell Cycle Arrest
Positive Regulation Of Hair Follicle Cell Proliferation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
PI3K Cascade
PIP3 activates AKT signaling
FGFR1b ligand binding and activation
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Regulation of gene expression in early pancreatic precursor cells
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Signaling by FGFR2 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
Primary torsion dystonia (PTD)
Aplasia of lacrimal and salivary glands
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
GWAS
Pelvic organ prolapse (moderate/severe) (
26545240
)
Alzheimer disease and age of onset (
26830138
)
Basal cell carcinoma (
31174203
)
Breast cancer (
29059683
31757997
)
Dentures (
31235808
)
Estimated glomerular filtration rate (
31152163
)
FEV1 (
30804560
)
High altitude adaptation (
28373541
)
Keratinocyte cancer (MTAG) (
31174203
)
Lung function (FVC) (
30804560
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Number of decayed, missing and filled tooth surfaces or use of dentures (
31235808
)
Parkinson's disease (
26227905
)
Prostate cancer (
21743467
)
Refractive error (
32231278
)
Interacting Genes
105 interacting genes:
ABCF3
ACOT7
AEBP2
AKAP17A
AKAP9
AP2B1
APP
ARL6IP4
BAG5
BEND7
BMS1P1
BYSL
C1orf216
C1orf35
C4orf45
C7orf50
CDC37
CDKN2D
CHD2
CSNK2A1
DCAF8
DVL2
EEF1AKNMT
FAM124A
FAM133A
FAM9A
FGF10
FGF11
FGF12
FXR2
GAS8
GPATCH2L
HNRNPLL
HYPK
INO80B
KANK2
KLF12
KRTAP10-7
L3MBTL2
LASP1
LMNB2
LMO3
LNX1
MFAP1
MIS18A
MORF4L1
MORF4L2
MRPL11
MRPL53
NDUFAB1
NKAP
NKAPD1
NTAQ1
NUP62
PAWR
PHF1
PHF19
PID1
PNKP
POLR2L
POLR2M
POU6F2
PPIG
PRKAA1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QKI
RAD54L2
RALY
RALYL
RBM10
RBM39
RIPPLY1
RNF4
RP9P
RPL22
RPS25
SAP30BP
SERF2
SLU7
SPANXN2
SREK1IP1
STRBP
TCEA2
TCEANC
TPM3
TRAF5
TRIM26
TRIP10
TTLL10
TXN2
U2AF2
UBE2I
VCX2
WT1
YES1
ZBTB48
ZCCHC10
ZGPAT
ZNF385C
ZNF408
ZNF526
6 interacting genes:
FBXO7
FGFR1
FGFR2
POMC
SREK1IP1
THAP1
Entrez ID
55145
2255
HPRD ID
15496
03665
Ensembl ID
ENSG00000131931
ENSG00000070193
Uniprot IDs
Q9NVV9
O15520
PDB IDs
2JTG
2KO0
2L1G
1NUN
Enriched GO Terms of Interacting Partners
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