THAP1 and TPM3

Data Source:
BioGRID (two hybrid)

		THAP1	TPM3
Description		THAP domain containing 1	tropomyosin 3
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body Intracellular Membrane-bounded Organelle	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Molecular_function Protein Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Cycle Regulation Of Mitotic Cell Cycle	Muscle Contraction Actin Filament Organization Muscle Filament Sliding
Pathways			Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Phenethyl Isothiocyanate
Diseases		Primary torsion dystonia (PTD)	Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 C4orf45 C7orf50 CDC37 CDKN2D CHD2 CSNK2A1 DCAF8 DVL2 EEF1AKNMT FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GAS8 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526	59 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CAVIN3 CCDC102B CCDC146 CCHCR1 CHRM3 CNN1 DVL2 FAM9C FBXO5 FGA HDDC3 HOOK2 HSF2 HSF4 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 MAST2 NEK2 NOD2 NUP54 ODAD1 OIP5 PBX3 PHLDB3 PSMC5 S100A2 S100A4 SMAD3 SNAPIN SUMO4 SYCE1 TAB2 TFPT THAP1 THAP7 TLK1 TMOD1 TMOD2 TNNI1 TNNT1 TPM4 TRAP1 TRIM27 TRIP6 TSKS VPS52 WASH3P WASHC1
Entrez ID		55145	7170
HPRD ID		15496	01840
Ensembl ID		ENSG00000131931	ENSG00000143549
Uniprot IDs		Q9NVV9	A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4I4 B4DQ80 P06753
PDB IDs		2JTG 2KO0 2L1G	6OTN
Enriched GO Terms of Interacting Partners?
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