BMP2 and ACVR1

Data Source:
HPRD (in vivo)

		BMP2	ACVR1
Description		bone morphogenetic protein 2	activin A receptor type 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Intracellular Membrane-bounded Organelle BMP Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex
	Molecular Function	Retinol Dehydrogenase Activity Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Phosphatase Activator Activity Co-receptor Binding SMAD Binding BMP Receptor Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPK Activity Skeletal System Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation BMP Signaling Pathway Involved In Heart Induction Aortic Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Atrium Formation Endocardial Cushion Formation Negative Regulation Of Wnt Signaling Pathway Involved In Heart Development Positive Regulation Of Extracellular Matrix Constituent Secretion Proteoglycan Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Notch Signaling Pathway Cell-cell Signaling Heart Development Negative Regulation Of Cell Population Proliferation Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Positive Regulation Of Phosphatase Activity Telencephalon Development Telencephalon Regionalization Positive Regulation Of Wnt Signaling Pathway Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Protein Destabilization Positive Regulation Of Protein Binding Negative Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Osteoblast Proliferation Cardiocyte Differentiation Embryonic Heart Tube Anterior/posterior Pattern Specification Bone Mineralization Involved In Bone Maturation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Inner Ear Development Negative Regulation Of Calcium-independent Cell-cell Adhesion Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Pericardium Development Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Mesenchyme Development Positive Regulation Of Wnt Signaling Pathway By BMP Signaling Pathway Positive Regulation Of Cartilage Development BMP Signaling Pathway Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Cyclic Compound Cellular Response To BMP Stimulus Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cardiac Jelly Development Atrioventricular Canal Morphogenesis Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Cardiac Muscle Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cardiac Muscle Cell Fate Commitment BMP Signaling Pathway Involved In Heart Development Endocardial Cushion Cell Fate Commitment Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by BMP Molecules associated with elastic fibres Transcriptional regulation by RUNX2 Regulation of RUNX2 expression and activity
Drugs			ATP Dorsomorphin Fostamatinib
Diseases			Fibrodysplasia ossificans progressiva (FOP)
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 29892015) Axial length ( 24144296) Body mass index ( 19079261 23669352 28892062 25673413) Body size at age 10 ( 32376654) Childhood ear infection ( 27182965) Colorectal cancer ( 25990418 30529582 26151821 29471430 24737748 31826910 23266556) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder (stressful life events interaction) ( 26845276) Nose morphology (partial least square model) ( 30174134) Obesity-related traits ( 23251661) Optic cup area ( 25631615 31798171 28073927) Peak expiratory flow ( 30804560) Pulse pressure ( 30224653) QRS complex (Cornell) ( 27659466) Refractive error ( 23396134 32231278) Retinal detachment or retinal break ( 31816047) Sagittal craniosynostosis ( 23160099) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels x loop diuretics use interaction ( 31806883) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Severe gingival inflammation ( 28459102)
Interacting Genes		21 interacting genes: ACTR2 ACVR1 ACVR2A ACVR2B ASCL1 BMPER BMPR1A BMPR1B BMPR2 CHRD CHRDL2 COL2A1 ENG GREM1 GREM2 MGP NOG RGMB SOSTDC1 TGFB1 TGFB2	70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TDGF1 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61
Entrez ID		650	90
HPRD ID		00206	00021
Ensembl ID		ENSG00000125845	ENSG00000115170
Uniprot IDs		C8C060 P12643	D3DPA4 Q04771
PDB IDs		1ES7 1REU 1REW 2GOO 2H62 2H64 2QJ9 2QJA 2QJB 3BK3 3BMP 4MID 4N1D 4UHY 4UHZ 4UI0 4UI1 4UI2 6OMN	3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6Z36 6ZGC 7A21
Enriched GO Terms of Interacting Partners?
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