SIM2 and CRYAA

Data Source:
BioGRID (genetic interference)

		SIM2	CRYAA
Description		SIM bHLH transcription factor 2	crystallin alpha A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Nuclear Body	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Heterodimerization Activity	Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Identical Protein Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development	Visual Perception Negative Regulation Of Intracellular Transport Protein Refolding Negative Regulation Of Apoptotic Process Protein Stabilization Response To Stimulus
Pathways
Drugs
Diseases
GWAS		Asthma and hay fever ( 24388013) Cerebellum cortex volume ( 31530798) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Night sleep phenotypes ( 27126917) Red blood cell count ( 27863252)	Age-related nuclear cataracts ( 33311586 24951543) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 28739976 27618452)
Interacting Genes		4 interacting genes: ARNT ARNT2 MAGED1 PRKN	18 interacting genes: ALB BCL2L1 CRYAA2 CRYAB CRYBA1 CRYBB2 CRYGC CRYGD CRYZ CS GORASP2 HSPB1 HSPB2 LALBA MIP NTAQ1 SDCBP SPG21
Entrez ID		6493	1409
HPRD ID		02935	00427
Ensembl ID		ENSG00000159263	ENSG00000160202
Uniprot IDs		Q14190	A0A140G945 P02489
PDB IDs			6T1R
Enriched GO Terms of Interacting Partners?
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