RASAL3 and RABGEF1

Data Source:
BioGRID (two hybrid)

		RASAL3	RABGEF1
Description		RAS protein activator like 3	RAB guanine nucleotide exchange factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Membrane Extracellular Exosome Cytoplasmic Side Of Membrane	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	GTPase Activator Activity Protein Binding Identical Protein Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	MAPK Cascade Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of NK T Cell Proliferation	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity
Pathways		Regulation of RAS by GAPs	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)
Interacting Genes		23 interacting genes: AMOTL2 BEGAIN CCDC102B CCDC136 CDR2L DEF6 HNRNPK HOMER1 KHDRBS3 KRT27 MTUS2 NTAQ1 PICK1 PPP1R13B PRKAA2 RABGEF1 RASD1 SNRPA TP53BP2 WASF3 YWHAE YWHAZ ZRANB1	50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C
Entrez ID		64926	27342
HPRD ID		10977	11477
Ensembl ID		ENSG00000105122	ENSG00000154710
Uniprot IDs		Q86YV0	A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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