RASAL3 and WASF3

Data Source:
BioGRID (two hybrid)

		RASAL3	WASF3
Description		RAS protein activator like 3	WASP family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Cortex Membrane Extracellular Exosome Cytoplasmic Side Of Membrane	Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Identical Protein Binding	Actin Binding Protein Kinase A Regulatory Subunit Binding Arp2/3 Complex Binding
	Biological Process	MAPK Cascade Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of NK T Cell Proliferation	Cytoskeleton Organization Regulation Of Cell Shape Oligodendrocyte Development Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Myelination Protein-containing Complex Assembly Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of RAS by GAPs	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Hallux valgus ( 32131869) Left-handedness ( 32989287) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Sporadic pituitary adenoma ( 26029870) Systolic blood pressure ( 30224653)
Interacting Genes		23 interacting genes: AMOTL2 BEGAIN CCDC102B CCDC136 CDR2L DEF6 HNRNPK HOMER1 KHDRBS3 KRT27 MTUS2 NTAQ1 PICK1 PPP1R13B PRKAA2 RABGEF1 RASD1 SNRPA TP53BP2 WASF3 YWHAE YWHAZ ZRANB1	12 interacting genes: ABI2 ACTB ACTR3 BYSL CAMK2D CKS1B EGFR KANK2 KIFC3 PIK3R1 PIK3R2 RASAL3
Entrez ID		64926	10810
HPRD ID		10977	05458
Ensembl ID		ENSG00000105122	ENSG00000132970
Uniprot IDs		Q86YV0	Q5T8P4 Q9UPY6
PDB IDs
Enriched GO Terms of Interacting Partners?
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