RABGEF1 and TXN2

Data Source:
BioGRID (two hybrid)

		RABGEF1	TXN2
Description		RAB guanine nucleotide exchange factor 1	thioredoxin 2
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GO Annotations	Cellular Component	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome	Nucleolus Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity Protein Disulfide Oxidoreductase Activity Peptide-methionine (R)-S-oxide Reductase Activity Protein-containing Complex Binding
	Biological Process	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity	Sulfur Amino Acid Catabolic Process Response To Hypoxia Glycerol Ether Metabolic Process Response To Oxidative Stress Response To Hormone Response To Glucose Response To Organic Cyclic Compound Cellular Response To Nutrient Levels Response To Drug Cell Redox Homeostasis Response To Axon Injury
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)
Interacting Genes		50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	79 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 BHLHB9 C11orf49 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B DCTD DDIT3 ETHE1 FAM9B FHL5 FMNL2 GOLGA6L9 GPRASP2 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32
Entrez ID		27342	25828
HPRD ID		11477	07161
Ensembl ID		ENSG00000154710	ENSG00000100348
Uniprot IDs		A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41	Q99757
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U	1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?
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