USP46 and H2BC21

Data Source:
BioGRID (enzymatic study)

		USP46	H2BC21
Description		ubiquitin specific peptidase 46	H2B clustered histone 21
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GO Annotations	Cellular Component	Nucleus Cytosol Glutamatergic Synapse	Nucleosome Extracellular Space Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Behavioral Fear Response Ubiquitin-dependent Protein Catabolic Process Adult Feeding Behavior Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Synaptic Transmission, GABAergic Behavioral Response To Ethanol Righting Reflex Regulation Of Postsynaptic Neurotransmitter Receptor Internalization	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Height ( 31562340) Platelet count ( 29403010) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		7 interacting genes: GRIA1 H2AC20 H2BC21 MAPK8IP2 UBA52 UBC WDR20	77 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BARD1 BRD2 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA H2AC20 HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SMU1 SPANXN2 SSRP1 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1
Entrez ID		64854	8349
HPRD ID		07507	03494
Ensembl ID		ENSG00000109189	ENSG00000184678
Uniprot IDs		P62068	Q16778
PDB IDs		5CVM 5CVN 5CVO 5L8H 6JLQ	4NFT 6A7U 6KBB 6M4D 6M4G 6M4H
Enriched GO Terms of Interacting Partners?
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