MARCHF7 and UBE2M

Data Source:
BioGRID (two hybrid)

		MARCHF7	UBE2M
Description		membrane associated ring-CH-type finger 7	ubiquitin conjugating enzyme E2 M
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding MDM2/MDM4 Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity
	Biological Process	Regulation Of Tolerance Induction Protein Monoubiquitination Positive Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Protein Autoubiquitination Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Protein Autoubiquitination	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways			TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		20 interacting genes: CTNNA3 EXOC8 HSF2BP IQCB1 MAPRE1 MAPRE3 MAPT PPP3CA PPP3CB RNF111 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2K UBE2M UBE2N USP7	30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		64844	9040
HPRD ID		09817	04414
Ensembl ID		ENSG00000136536	ENSG00000130725
Uniprot IDs		B7Z5K0 B7ZAR7 F5H6W4 Q9H992	A0A024R4T4 P61081
PDB IDs			1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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