MICAL1 and DNAH5

Data Source:
BioGRID (biochemical)

		MICAL1	DNAH5
Description		microtubule associated monooxygenase, calponin and LIM domain containing 1	dynein axonemal heavy chain 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Actin Cytoskeleton Midbody Intercellular Bridge Hippocampal Mossy Fiber Expansion	Extracellular Region Cytoplasm Microtubule Axoneme Dynein Complex Motile Cilium Outer Dynein Arm 9+2 Motile Cilium
	Molecular Function	Actin Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding	ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Blood Coagulation Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Lateral Ventricle Development Flagellated Sperm Motility Outer Dynein Arm Assembly Establishment Of Localization In Cell Cilium Assembly
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Depression in smokers ( 30219690) Height ( 28552196)	Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Coffee consumption ( 29367735) Corneal astigmatism ( 23322567) Emphysema imaging phenotypes ( 26030696) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) IgE grass sensitization ( 22036096) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Subclinical atherosclerosis traits (other) ( 17903303) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) ( 27515689) Visceral fat ( 22589738)
Interacting Genes		16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM	1 interacting genes: MTDH
Entrez ID		64780	1767
HPRD ID		06183	04514
Ensembl ID		ENSG00000135596	ENSG00000039139
Uniprot IDs		Q8TDZ2	Q8TE73
PDB IDs		1WYL 2CO8 2DK9 5LE0 5LPN 6KU0
Enriched GO Terms of Interacting Partners?
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