FBXW4 and A2M

Data Source:
BioGRID (two hybrid)

		FBXW4	A2M
Description		F-box and WD repeat domain containing 4	alpha-2-macroglobulin
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Embryonic Limb Morphogenesis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Heel bone mineral density ( 30598549)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: A2M CDC37 CUL1 ECSIT MAST1 RNF32	96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		6468	2
HPRD ID		06994	00072
Ensembl ID		ENSG00000107829	ENSG00000175899
Uniprot IDs		A0A384P5X9 P57775	P01023
PDB IDs			1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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