SGTA and BAG6

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid)

		SGTA	BAG6
Description		small glutamine rich tetratricopeptide repeat co-chaperone alpha	BAG cochaperone 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane TRC Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome BAT3 Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding	Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Misfolded Protein Binding Proteasome Binding Ubiquitin-specific Protease Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Viral Process Ubiquitin-dependent ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Kidney Development Immune Response-activating Cell Surface Receptor Signaling Pathway Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Synaptonemal Complex Assembly Spermatogenesis Brain Development Proteasomal Protein Catabolic Process Internal Peptidyl-lysine Acetylation Natural Killer Cell Activation Cell Differentiation Lung Development Ubiquitin-dependent ERAD Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Proteolysis Regulation Of Embryonic Development Protein Stabilization Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ER-associated Misfolded Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of ERAD Pathway Maintenance Of Unfolded Protein Involved In ERAD Pathway Protein Localization To Cytosolic Proteasome Complex Involved In ERAD Pathway
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Height ( 28552196) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 23894747) Small cell lung carcinoma ( 28604730) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28067908)
Interacting Genes		176 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B	118 interacting genes: ACVR1B AMFR AMTN ANTKMT ANXA7 APBB1IP ARPC3 ATN1 ATXN2 B2M C1QA CD93 CDK16 CDK4 CDK5 CDKN1A CDSN CHN2 CILK1 CLU CSNK2B CSTF2 CTAG1A CTAG1B CTCFL CTSB CTSE CTSL CXCL8 CYSRT1 DMKN DNAJB11 DPT EDN1 EFEMP1 EFEMP2 ELP1 EP300 FAM9B FAS FKBP2 FZD4 GADD45A GET4 GLRA2 GOLGA6L9 GSK3B HSPA13 HSPA8 IGF2 IGFBP5 IMMT IQCG KLHL12 KPNA2 LBP MAPK6 MEST MTNR1A MYDGF NBL1 NCR3 NDUFA6 NDUFB11 NOMO1 NPY NR1H2 PELP1 PIN1 PLA2G2A PLK1 PLPP2 PLPPR3 POLR2J PRKAR1B PRMT2 PRNP PRPF40A PTH PTN PTPN12 RAB8A RAC1 RCC1 RCN2 REG1B RNF126 S100A4 SDC2 SEC61A1 SEC61B SERPING1 SERPINH1 SERPINI2 SETDB1 SGTA SMN1 SPP1 SRGN STX5 TAC1 TDGF1 TENT5A TFCP2 TK1 TOMM20 TP53 TP63 TTR UBL4B UBL7 UBQLN1 UBQLN2 UBQLN4 USP13 VAMP2 XRN1 ZFYVE9
Entrez ID		6449	7917
HPRD ID		04568	00808
Ensembl ID		ENSG00000104969	ENSG00000204463
Uniprot IDs		O43765	A0A1U9X7A6 P46379
PDB IDs		2VYI 4CPG 4GOD 4GOE 4GOF	1WX9 2N9P 4DWF 4EEW 4WWR 4X86 6AU8
Enriched GO Terms of Interacting Partners?
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