AKTIP and HOOK3

Data Source:
HPRD (in vivo)

		AKTIP	HOOK3
Description		AKT interacting protein	hook microtubule tethering protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane HOPS Complex FHF Complex	Pericentriolar Material Cytoplasm Cis-Golgi Network Centrosome Cytosol Microtubule HOPS Complex Centriolar Satellite FHF Complex
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Microtubule Binding Dynactin Binding Identical Protein Binding Dynein Light Chain Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Protein Phosphopantetheinylation Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Early Endosome To Late Endosome Transport Negative Regulation Of Neurogenesis Golgi Localization Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Zinc levels ( 26025379)
Interacting Genes		34 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41	11 interacting genes: AKTIP CTIF HOOK1 HOOK2 KRT13 KRT27 MAPT MEOX2 PNMA5 VPS16 VPS41
Entrez ID		64400	84376
HPRD ID		07467	09699
Ensembl ID		ENSG00000166971	ENSG00000168172
Uniprot IDs		A0A024R6S6 A0A024R6T5 Q9H8T0	Q86VS8
PDB IDs			5J8E 6B9H
Enriched GO Terms of Interacting Partners?
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