HOOK3 and VPS16

Data Source:
HPRD (in vivo)

		HOOK3	VPS16
Description		hook microtubule tethering protein 3	VPS16 core subunit of CORVET and HOPS complexes
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GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Cis-Golgi Network Centrosome Cytosol Microtubule HOPS Complex Centriolar Satellite FHF Complex	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Axon HOPS Complex Late Endosome Membrane Neuronal Cell Body Recycling Endosome
	Molecular Function	Protein Binding Microtubule Binding Dynactin Binding Identical Protein Binding Dynein Light Chain Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Early Endosome To Late Endosome Transport Negative Regulation Of Neurogenesis Golgi Localization Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance	Intracellular Protein Transport Vacuole Organization Endosome To Lysosome Transport Endosomal Transport Vacuole Fusion, Non-autophagic Autophagosome Maturation
Pathways
Drugs
Diseases
GWAS		Zinc levels ( 26025379)	Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: AKTIP CTIF HOOK1 HOOK2 KRT13 KRT27 MAPT MEOX2 PNMA5 VPS16 VPS41	17 interacting genes: AKTIP EXOC8 FBXO7 GNG13 HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP STX1A STX7 UVRAG VPS11 VPS18 VPS33A ZNF417
Entrez ID		84376	64601
HPRD ID		09699	12259
Ensembl ID		ENSG00000168172	ENSG00000215305
Uniprot IDs		Q86VS8	Q9H269
PDB IDs		5J8E 6B9H	4BX9
Enriched GO Terms of Interacting Partners?
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