HOOK3 and VPS41

Data Source:
HPRD (in vivo)

		HOOK3	VPS41
Description		hook microtubule tethering protein 3	VPS41 subunit of HOPS complex
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Cis-Golgi Network Centrosome Cytosol Microtubule HOPS Complex Centriolar Satellite FHF Complex	Lysosomal Membrane Early Endosome Late Endosome Golgi Apparatus Golgi-associated Vesicle Endosome Membrane Microtubule Cytoskeleton AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane Clathrin Complex
	Molecular Function	Protein Binding Microtubule Binding Dynactin Binding Identical Protein Binding Dynein Light Chain Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Binding Microtubule Binding Identical Protein Binding Protein Self-association Metal Ion Binding
	Biological Process	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Early Endosome To Late Endosome Transport Negative Regulation Of Neurogenesis Golgi Localization Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance	Protein Targeting To Vacuole Endosome To Lysosome Transport Cellular Response To Starvation Macroautophagy Endosomal Vesicle Fusion Regulated Exocytosis Late Endosome To Lysosome Transport
Pathways
Drugs
Diseases
GWAS		Zinc levels ( 26025379)	Breast cancer and/or colorectal cancer ( 29698419) Cognitive performance ( 19734545)
Interacting Genes		11 interacting genes: AKTIP CTIF HOOK1 HOOK2 KRT13 KRT27 MAPT MEOX2 PNMA5 VPS16 VPS41	12 interacting genes: AKTIP AP3D1 APP ARL8B HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP UBE2U ZNF512B
Entrez ID		84376	27072
HPRD ID		09699	10402
Ensembl ID		ENSG00000168172	ENSG00000006715
Uniprot IDs		Q86VS8	P49754
PDB IDs		5J8E 6B9H
Enriched GO Terms of Interacting Partners?
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